Full Title: Failure to Detect Xenotropic Murine Leukemia Virus-Related Virus in Blood of Individuals at High Risk of Blood-Borne Viral Infections.
Authors: Barnes E, Flanagan P, Brown A, Robinson N, Brown H, McClure M, Oxenius A, Collier J, Weber J, Günthard HF, Hirschel B, Fidler S, Phillips R, Frater J.
Publication: The Journal of Infectious Diseases
Publication Date: 15th November 2010
Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, The James Martin 21st Century School, at The Peter Medawar Building for Pathogen Research, South Parks Road, Department of Gastroenterology, John Radcliffe Hospital NHS Trust, Oxford, Division of Medicine, Wright Fleming Institute, Imperial College London, St. Mary's Hospital, London, United Kingdom; Institute of Microbiology, ETH Zurich, Division of Infectious Diseases and Hospital Epidemiology, University Hospital, University of Zurich, Zurich, and Division of Infectious Diseases, University Hospital, CH-1211 Geneva, Switzerland.
A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe.