Full title: Xenotropic murine leukaemia virus-related virus is not found in peripheral blood cells from treatment-naive human immunodeficiency virus-positive patients.
Authors: Maggi F, Focosi D, Lanini L, Sbranti S, Mazzetti P, Macera L, Davini S, De Donno M, Mariotti ML, Antonelli G, Scatena F, Pistello M.
Source Virology Unit, Pisa University Hospital U.O. Immunoematologia SSN, Azienda Ospedaliera Universitaria Pisana, Pisa Laboratory of Virology, Department of Molecular Medicine, 'Sapienza' University of Rome, Rome Retrovirus Centre and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy.
Publication: Clin Microbiol Infect.
Publication date: 18 May 2011
The human pathogen xenotropic murine leukaemia virus-related virus (XMRV) has been tentatively associated with prostate cancer and chronic fatigue syndrome. Unfortunately, subsequent studies failed to identify the virus in various clinical settings. To determine whether XMRV circulates in humans and the relationship with its host, we searched for the virus in 124 human immunodeficiency virus-infected patients who might have been exposed to XMRV, might be prone to infection as a result of progressive immunodeficiency, and had not yet been treated with antiretroviral drugs. Using nested PCR and single-step TaqMan real-time PCR, both designed on the XMRV gag gene, we could not find any positive samples. These findings add to the growing amount of scepticism regarding XMRV.
© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.
PMID:21672082[PubMed - as supplied by publisher]
View the abstract in PubMed.