Full title: The left half of XMRV is present in an endogenous retrovirus of NIH/3T3 Swiss mouse cells.
Authors: Mendoza R, Vaughan AE, Miller AD.
Source: Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Publication: J Virol.
Publication date: 22 Jun 2011
Abstract
Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus found in association with human prostate cancer and chronic fatigue syndrome, although these associations are controversial. XMRV shows at most 94% identity to known mouse retroviruses. Here we used XMRV-specific PCR to search for a more closely related source of XMRV in mice. While we could not find a complete copy, we did find a 3,600 bp region of XMRV in an endogenous retrovirus present in NIH/3T3 cells. These results show that XMRV has clear ancestors in mice, and highlight another possible source of contamination in PCR assays for XMRV.
PMID:21697491[PubMed - as supplied by publisher]
View the abstract in PubMed.
