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Health & care professionals

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There has been considerable under-investment in M.E. research by mainstream funders. This desperately needs to change and, over the past couple of years, we have seen momentum gaining.

There is now growing evidence from experts in the field that a number of sub-groups (phenotypes) exist within M.E. Individuals in these sub-groups – which still need more research to be identified – differ in terms of their illness experience and the course their illness follows.

Evidence is emerging for possible phenotypes relating to:

  • postural orthostatic tachycardia syndrome (Newton et al, 2013, Journal of Internal Medicine)
  • brain dysfunction (Natelson, 2013, Frontiers in Physiology)
  • gene expression changes following exercise (Light et al, 2012, Journal of Internal Medicine).

Key papers have been published on:

  • defining post-exertional malaise and sudden onset of M.E. (both Jason et al, 2015, Journal of Prevention and Intervention in the Community)
  • discriminative validity of metabolic and workload measurements (Van Ness et al, 2013, Journal of Physical Therapy)
  • brain abnormalities (Zeineh et al, 2014, Radiology)
  • brain inflammation (Nakatomi et al, 2014, Journal of Nuclear Medicine)
  • altered immune response to exercise (Nijs et al, 2014, International Society of Exercise and Immunology)
  • loss of capacity to recover from acidosis on repeat exercise (Jones et al, 2012, European Journal of Clinical Investigation)
  • using the DePaul Symptom Questionnaire to assess symptoms (Brown and Jason, 2014, Biomedicine, Health & Behavior).

To keep up to date with the latest published research on M.E., visit our News page and click on Research news.